![]() Improve the long-term survival rate of patients ( 4, 5). Stage, which can completely remove the non-metastatic lesions to Most preferred and primary treatment for lung cancer at an early The latter three types are recognized collectively as non-smallĬell lung cancer, which accounts for ~85% of all lung cancers May be divided into four major types: Small-cell lung carcinoma,Īdenocarcinoma, squamous cell carcinoma and large cell carcinoma. Lung cancer, which is also termed lung carcinoma, The morbidity of lungĬancer has continuously increased and the overallįive-year-survival rate is ~15% ( 1), which poses a threat to public Malignancy-associated mortality worldwide. Lung cancer is the leading cause of tumor In conclusion, isofraxidin may be a novel candidate for anti‑lung cancer chemotherapy. In addition, despite the inhibitory effects on the A549 lung cancer cell line, the present study revealed that isofraxidin exhibited low toxicity towards BEAS‑2B normal lung epithelial cells within a certain dose range (0‑160 µM), indicating that isofraxidin may be employed for lung cancer treatment with hypotoxicity and fewer side effects. This regulation of protein expression may contribute to the inhibition of proliferation, migration and invasion of A549lung cancer cells by isofraxidin. Furthermore, western blot analysis demonstrated that isofraxidin treatment led to effects on the expression of apoptosis‑associated proteins, including members of the Bcl‑2 protein family, and invasion‑associated proteins, including matrix metallopeptidase (MMP)‑2 and MMP‑9, which may occur via inhibition of the expression of phosphorylated (p)‑epidermal growth factor receptor, p‑AKT and p‑extracellular signal‑regulated kinase. The results of Cell Counting kit‑8, Transwell migration and Matrigel invasion assays, and flow cytometry to determine apoptosis, revealed that isofraxidin significantly inhibited the proliferation, migration and invasion of A549 cells, and induced the cell apoptosis. The results revealed that, in vivo and in vitro, isofraxidin exhibited marked inhibitory effects on the A549 lung cancer cell line. In the present study, the effects of isofraxidin on lung cancer cells and the associated mechanisms were investigated. Therefore, it is of great importance to investigate anti‑lung cancer drugs with high efficiency and low toxicity. In recent years, the treatment of lung cancer with chemotherapy has demonstrated notable resistance and insensitivity. Lung cancer is the leading cause of mortality due to tumor malignancy worldwide. ![]()
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